Adewale Akinnuoye-Agbaje
- Marvel: "Thor: The Dark World" (2013) as Algrim/Kurse
- DC: "Suicide Squad" (2016) as Killer Croc
Alan Tudyk
- Marvel: "Deadpool 2" (2018) as Redneck #2
- DC: "Doom Patrol" (2019-present) as Mr. Nobody
Angela Bassett
- Marvel: "Black Panther" (2018) as Ramonda
- DC: "Green Lantern" (2011) as Amanda Waller
Barry Keoghan
- Marvel: "Eternals" (2021) as Druig
- DC: "The Batman" (2022) as The Joker
Ben Affleck
- Marvel: "Daredevil" (2003) as Daredevil
- DC: "Batman v Superman: Dawn of Justice" (2016) as Batman
Benjamin Bratt
- Marvel: "Doctor Strange" (2016) as Jonathan Pangborn
- DC: "Catwoman" (2004) as Tom Lone
Blake Lively
- Marvel: Deadpool & Wolverine (2024) as Lady Deadpool
- DC: "Green Lantern (2011)" as Carol Ferris
Christian Bale
- Marvel: "Thor: Love and Thunder" (2022) as Gorr the God Butcher
- DC: "The Dark Knight" series (2005-2012) as Batman
Ciarán Hinds
- Marvel: "Ghost Rider: Spirit of Vengeance" (2011) as Roarke
- DC: "Justice League" (2017) as Steppenwolf (voice)
Clancy Brown
- Marvel: "Thor: Ragnarok" (2017) as Surtur (voice)
- DC: "Justice League Animated Movies" (1996 - 2018) as Lex Luthor (voice)
- DC: "The Flash" (2014-2015) as General Wade Eiling
Chris Evans
- Marvel: "Captain America" series (2011-2019) as Captain America
- Marvel: "Fantastic Four" (2005) as Johnny Storm
- DC: "The Losers" (2010) as Jensen
Colin Farrell
- Marvel: "Daredevil" (2003) as Bullseye
- DC: "The Batman" (2022) as Penguin
Colm Feore
- Marvel: "Thor" (2011) as King Laufey
- DC: "Gotham" (2014) as Dr. Francis Dulmacher
Danny Huston
- Marvel: "X-Men Origins: Wolverine" (2009) as William Stryker
- DC: "Wonder Woman" (2017) as General Ludendorff
David Dastmalchian
- Marvel: "Ant-Man" series (2015-2018) as Kurt
- DC: "The Dark Knight" (2008) as Thomas Schiff
- DC: "The Suicide Squad" (2021) as Polka-Dot Man
David Harbour
- Marvel: "Black Widow" (2021) as Alexei Shostakov/Red Guardian
- DC: "Suicide Squad" (2016) as Dexter Tolliver
David Tennant:
- Marvel: "Jessica Jones" (2015-2019) as Kilgrave
- DC: "Teen Titans Go! To the Movies" (2018) as Balloon Man (voice)
Djimon Hounsou
- Marvel: "Guardians of the Galaxy" (2014) , "Captain Marvel" (2019) as Korath the Pursuer
- DC: "Constantine" (2005) as Midnite
- DC: "Aquaman" (2018) as The Fisherman King (King Ricou)
- DC: "Shazam!" (2019) , Shazam! Fury of the Gods" (2023) as The Wizard Shazam
Dolph Lundgren
- Marvel: "The Punisher" (1989) as Frank Castle
- DC: "Aquaman" (2018) as King Nereus
Elliot Page
- Marvel: "X-Men" series (2006-2014) as Kitty Pryde
- DC: "The Umbrella Academy" (2019-present) as Vanya Hargreeves
Halle Berry
- Marvel: "X-Men" series (2000-2014) as Storm
- DC: "Catwoman" (2004) as Catwoman
Henry Cavill
- Marvel: "Deadpool & Wolverine" (2024) as Wolverine
- DC: "Man of Steel (2013), Batman v Superman: Dawn of Justice (2016), Justice League (2017), Zack Snyder's Justice League (2021)" as Clark Kent/Superman
Hugo Weaving
- Marvel: "Captain America: The First Avenger" (2011) as Red Skull
- DC: "V for Vendetta" (2005) as V
Idris Elba
- Marvel: "Thor" series (2011-2017) as Heimdall
- DC: "The Suicide Squad" (2021) as Bloodsport
J. K. Simmons
- Marvel: "Spider-Man" series (2002-2007) as J. Jonah Jameson
- DC: "Justice League" (2017) as Commissioner Gordon
James Marsden
- Marvel: "X-Men" series (2000-2014) as Cyclops
- DC: "Superman Returns" (2006) as Richard White
Jared Leto
- Marvel: "Morbius" (2022) as Morbius
- DC: "Suicide Squad" (2016) as Joker
Joe Manganiello
- Marvel: "Spider-Man" (2002) as Flash Thompson
- DC: "Justice League" (2017) as Deathstroke
Jon Favreau
- Marvel: "Iron Man" series (2008-2013) as Happy Hogan
- DC: "Batman Forever" (1995) as Assistant
Joss Whedon (director)
- Marvel: "The Avengers" (2012), "Avengers: Age of Ultron" (2015)
- DC: "Justice League" (2017) (completed after Zack Snyder stepped down)
Josh Brolin
- Marvel: "Deadpool 2" (2018) as Cable
- Marvel: "Guardians of the Galaxy" (2014), "Avengers: Infinity War" (2018) as Thanos
- DC: "Jonah Hex" (2010) as Jonah Hex
Jurnee Smollett
- Marvel: "Captain America: The First Avenger" (2011) as Gail Richards
- DC: "Birds of Prey" (2020) as Black Canary
Kelly Hu
- Marvel: "X2: X-Men United" (2003) as Lady Deathstrike
- DC: "Arrow" (2012-2019) as China White
Laurence Fishburne
- Marvel: "Ant-Man and the Wasp" (2018) as Bill Foster
- DC: "Man of Steel" (2013) as Perry White
Matt Frewer:
- Marvel: "Generation X" (1996) as Russell Tresh
- DC: "Watchmen" (2009) as Moloch
Michael B. Jordan
- Marvel: "Fantastic Four" (2015) as Johnny Storm
- Marvel: "Black Panther" (2018) as Erik Killmonger
- DC: "Justice League: The Flashpoint Paradox" (2013) as Cyborg (voice)
Michael Chiklis
- Marvel: "Fantastic Four" series (2005-2007) as Ben Grimm/The Thing
- DC: "Gotham" (2015-2017) as Nathaniel Barnes/The Executioner
Michael Keaton
- Marvel: "Spider-Man: Homecoming" (2017) as Vulture
- DC: "Batman" (1989), "Batman Returns" (1992) as Batman
Michael Rooker
- Marvel: "Guardians of the Galaxy" series (2014-2017) as Yondu
- DC: "The Suicide Squad" (2021) as Savant
Michelle Pfeiffer
- Marvel: "Ant-Man and the Wasp" (2018) as Janet van Dyne
- DC: "Batman Returns" (1992) as Catwoman
Morena Baccarin
- Marvel: "Deadpool" series (2016-2018) as Vanessa
- DC: "Gotham" (2014-2019) as Leslie Thompkins
Nathan Fillion
- Marvel: "Guardians of the Galaxy" (2014) as Monstrous Inmate (voice)
- Marvel: "Guardians of the Galaxy Vol. 2" (2017) as Simon Williams (deleted scenes)
- Marvel: "Guardians of the Galaxy Vol. 3" (2023) as Master Karja
- Marvel: "Deadpool & Wolverine" (2024) as Headpool
- DC: "The Suicide Squad" (2021) as T.D.K.
- DC: "Green Lantern Animated Movies" (2011 - 2019) as Hal Jordan/Green Lantern (Voice)
Natalie Portman
- Marvel: "Thor" series as Jane Foster
- DC: "V for Vendetta" (2005) as Evey Hammond
Nicolas Cage
- Marvel: Ghost Rider (2007), Ghost Rider: Spirit of Vengeance (2011) as Johnny Blaze/Ghost Rider
- Marvel: Spider-Man: Into the Spider-Verse (2018) as Spider-Man Noir (Voice)
- DC: Teen Titans Go! To the Movies (2018) as Superman (Voice)
- DC: The Flash (2023) as Superman
Nicole Kidman
- Marvel: "Aquaman" (2018) as Atlanna
- DC: "Batman Forever" (1995) as Dr. Chase Meridian
Oscar Issac
- Marvel: "X-Men: Apocalypse" (2016) as En Sabah Nur / Apocalypse
- Marvel: "Moon Knight" (2022) as Marc Spector / Moon Knight
- Marvel: "Spider-Man: Into the Spider-Verse" (2018) & "Spider-Man: Across the Spider-Verse" (2023) as Miguel O'Hara / Spider-Man 2099 (voice)
Patrick Stewart
- Marvel: "X-Men" series (2000-2017) as Charles Xavier
- DC: "Green Lantern: The Animated Series" (2012) as Appa Ali Apsa (voice)
Patrick Wilson
- Marvel: LEGO Marvel Super Heroes: Maximum Overload as The President (voice)
- DC: "Watchmen" (2009) as Dan Dreiberg/Nite Owl
- DC: "Aquaman" (2018) as Orm/Ocean Master